TargetMol

PROTAC CDK2/9 Degrader-1

Product Code:
 
TAR-T12552
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
CAS:
2408641-24-5
Formula:
C40H41N13O7
Molecular Weight:
815.84
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
O=C(NC1=CC=C(C=C1)CN2CCN(C(=O)CCC(=O)NCCNC3=CC=CC=4C(=O)N(C(=O)C34)C5C(=O)NC(=O)CC5)CC2)C6=NNC=C6NC=7N=CN=C8NC=CC87
Target:
CDK

References

Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952.