TargetMol

JH-LPH-28

Product Code:
 
TAR-T11715
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T11715-100mg100mgEnquire
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TAR-T11715-500mg500mgEnquire
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Further Information

Bioactivity:
JH-LPH-28, a sulfonyl piperazine analog, is a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH, exhibiting exceptional antibiotic activity with a minimum inhibitory concentration (MIC) value of 0.83 ug/mL.
CAS:
2414592-36-0
Purity:
0.98
SMILES:
CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cc(F)cc(c1)C(F)(F)F

References

Cho J, et al. Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4109-4116.