TargetMol

Ibrutinib dimer

Product Code:
 
TAR-T11602
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Ibrutinib dimer is an impurity of Ibrutinib. IIbrutinib dimer is a Dimer of Ibrutinib. Ibrutinib is an irreversible Btk inhibitor (IC50: 0.5 nM).
CAS:
2031255-23-7
Formula:
C50H48N12O4
Molecular Weight:
880.99
Purity:
0.98
SMILES:
N(CCC(=O)N1C[C@@](CCC1)(N2C=3C(C(=N2)C4=CC=C(OC5=CC=CC=C5)C=C4)=C(N)N=CN3)[H])C6=C7C(N(N=C7C8=CC=C(OC9=CC=CC=C9)C=C8)[C@]%10(CN(C(C=C)=O)CCC%10)[H])=NC=N6

References

Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.