TargetMol

Gefitinib-d8

Product Code:
 
TAR-T11384
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T11384-100mg100mgEnquire
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TAR-T11384-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.
CAS:
857091-32-8
Formula:
C22H24ClFN4O3
Molecular Weight:
454.95
Purity:
0.98
SMILES:
N(C=1C2=C(C=C(OC)C(OCCCN3C(C(OC(C3([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

References

Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.