TargetMol

Afatinib N-Oxide

Product Code:
 
TAR-T10257
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Afatinib N-Oxide is an impurity of Afatinib in oxidative degradation. Afatinib is an irreversible EGFR family inhibitor.
CAS:
T10257
Formula:
C24H25ClFN5O4
Molecular Weight:
501.94
Purity:
0.98
SMILES:
ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/C[N+](C)([O-])C)=O)C(O[C@H]4CCOC4)=C3)=C1

References

Pawan kumar, et al. A controlled, efficient and robust process for the synthesis of an epidermal growth factor receptor inhibitor: Afatinib Dimaleate. Chem Rep, 2019, 1(1): 3-12.