TargetMol

TNKS-2-IN-1

Product Code:
 
TAR-T77675
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T77675-10mg10mg£95.00
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TAR-T77675-25mg25mg£111.00
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TAR-T77675-50mg50mg£149.00
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Quantity:
TAR-T77675-100mg100mg£220.00
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This product comes from: United States.
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Further Information

Bioactivity:
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the release of IL-1β from the NLRP3 inflammasome (IC50: 5 uM) by inhibiting IL-1β release from ATP-stimulated J1A.774 cells.
CAS:
4765-59-7
Molecular Weight:
267.24
Pathway:
Stem Cells|DNA Damage/DNA Repair|Microbiology/Virology|Chromatin/Epigenetic|Cytoskeletal Signaling
Purity:
0.98
SMILES:
O=C1N=C(C2=CC=C([N+]([O-])=O)C=C2)NC3=C1C=CC=C3
Target:
PARP|Wnt/beta-catenin|Antibiotic

References

Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.