TargetMol

PBT434 HBr

Product Code:
 
TAR-T71174
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71174-5mg5mg£1,010.00
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TAR-T71174-50mg50mg£1,982.00
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Quantity:
TAR-T71174-100mg100mg£2,560.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is greater than that of α-synuclein but lower than that of iron trafficking proteins, e.g., ferritin.
CAS:
1232841-78-9
Molecular Weight:
383.07
Purity:
0.98