TargetMol

AMG151 HCl

Product Code:
 
TAR-T70391
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T70391-5mg5mg£1,171.00
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TAR-T70391-50mg50mg£2,303.00
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Quantity:
TAR-T70391-100mg100mg£3,042.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug?drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesses good in vitro drug-like properties (aqueous solubility, cell permeability, low low potential for drug-drug interactions, low predicted hepatic clearance), and selectivity against broad panels of receptors and enzymes.
CAS:
1609674-80-7
Molecular Weight:
527.439
Purity:
0.98