TargetMol

DBPR112 HCl

Product Code:
 
TAR-T69498
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T69498-5mg5mg£930.00
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TAR-T69498-50mg50mg£1,821.00
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Quantity:
TAR-T69498-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib along with F = 41.5%, an encouraging safety profile, and significant antitumor efficacy in in vivo xenograft models.
CAS:
2889316-21-4
Molecular Weight:
570.09
Purity:
0.98