TargetMol

L82

Product Code:
 
TAR-T60753
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60753-5mg5mg£122.00
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TAR-T60753-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T60753-10mg10mg£155.00
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TAR-T60753-25mg25mg£229.00
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TAR-T60753-50mg50mg£322.00
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Quantity:
TAR-T60753-100mg100mg£470.00
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Quantity:
TAR-T60753-500mg500mg£938.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 uM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
CAS:
329227-30-7
Molecular Weight:
309.67
Pathway:
DNA Damage/DNA Repair
Purity:
0.9907
SMILES:
O=C1NN=CC(NN=CC2=CC=C(O)C(=C2)N(=O)=O)=C1Cl
Target:
DNA

References

Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017;60:29-39. Stowers RS, et al. The 82F late puff contains the L82 gene, an essential member of a novel gene family. Dev Biol. 1999;213(1):116-130. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008;68(9):3169-3177.