TargetMol

JMS-053

Product Code:
 
TAR-T60396
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60396-5mg5mg£404.00
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Quantity:
TAR-T60396-50mg50mg£1,532.00
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Quantity:
TAR-T60396-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
JMS-053 is equipotent to inhibit PTP4A3 and its close family members PTP4A1 and PTP4A2 with IC50s of 34.7 nM, 29.1 nM, and 48.0 nM. JMS-053 inhibits the oncogenic dual specificity phosphatase CDC25B with an IC50 value of 92.6 nM. JMS-053 is an inhibitor of the dual specificity phosphatase DUSP3 with IC50 of 207.6 nM. JMS-053 inhibited cancer cell migration and spheroid growth in vitro, attenuated in vivo ovarian tumor growth, and mitigated the disruption of the microvascular endothelial barrier function by vascular endothelial growth factor or lipopolysaccharide [1].
CAS:
1954650-11-3
Molecular Weight:
256.28
Purity:
0.98
SMILES:
N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1