TargetMol

FAM-DEALAHypYIPMDDDFQLRSF

Product Code:
 
TAR-T41173
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T41173-5mg5mgEnquire
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Further Information

Bioactivity:
FAM-DEALAHypYIPMDDDFQLRSF is a 5,6-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD= 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima (λ) = 485/520 nm. This product is a longer peptide version of FAM-DEALA-Hyp-YIPD.
Purity:
0.98

References

Crews et al (2018) Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. J.Med.Chem. 61 583 PMID: 28692295 Ahn et al (2009) HIF-1? peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1?. Bioorg.Med.Chem.Lett. 19 4403 PMID: 19515556 Buckley et al (2012) Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1a interaction. J.Am.Chem.Soc. 134 4465 PMID: 22369643