TargetMol

Fasudil

Product Code:
 
TAR-T1606
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T1606-5mg5mg£111.00
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TAR-T1606-10mg10mg£118.00
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TAR-T1606-25mg25mg£142.00
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TAR-T1606-50mg50mg£173.00
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TAR-T1606-100mg100mg£222.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
CAS:
103745-39-7
Formula:
C14H17N3O2S
Molecular Weight:
291.369
Pathway:
Cytoskeletal Signaling|Membrane transporter/Ion channel|Chromatin/Epigenetic|Stem Cells|Cell Cycle/Checkpoint|Metabolism|Autophagy|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
O=S(=O)(N1CCCNCC1)c1cccc2cnccc12
Target:
PKA|ROCK|Autophagy|Calcium Channel|PKC|Serine/threonin kinase

References

Negoro N, et al. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. Asano T, et al. Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. Asano T, et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100. Ono-Saito N, et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31.