TargetMol

VDR agonist 1

Product Code:
 
TAR-T13292
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T13292-5mg5mg£1,167.00
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TAR-T13292-50mg50mg£2,307.00
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Quantity:
TAR-T13292-100mg100mg£2,898.00
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Further Information

Bioactivity:
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with a low IC 50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle by the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 [1].
CAS:
2269494-43-9
Formula:
C32H51N3O2
Molecular Weight:
509.77
Purity:
0.98
SMILES:
O=C(C1=CC(C(CC)(C2=CC=C(/C=C/C(O)(CC)CC)C(C)=C2)CC)=CN1CC)NCCN(CC)CC

References

Wang C, et al. Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. Eur J Med Chem. 2019 Feb 1;163:787-803.