TargetMol

JBJ-02-112-05

Product Code:
 
TAR-T11713
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T11713-5mg5mg£850.00
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Quantity:
TAR-T11713-50mg50mg£1,661.00
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Quantity:
TAR-T11713-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].
CAS:
2748162-29-8
Formula:
C27H20N4O2S
Molecular Weight:
464.54
Pathway:
Chromatin/Epigenetic|Stem Cells|JAK/STAT signaling|Angiogenesis
Purity:
0.98
SMILES:
O=C(NC1=NC=CS1)C(N2C(C(C=C(C3=CC(C=CN4)=C4C=C3)C=C5)=C5C2)=O)C6=CC=CC=C6
Target:
JAK

References

To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943.