TargetMol

GNE684

Product Code:
 
TAR-T11442
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T11442-5mg5mg£850.00
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TAR-T11442-50mg50mg£1,661.00
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Quantity:
TAR-T11442-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1) with average Ki app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively [1].
CAS:
2438637-64-8
Formula:
C23H24N6O3
Molecular Weight:
432.48
Pathway:
Apoptosis
Purity:
0.98
SMILES:
COC1=NC=C(N(C)C([C@@H](NC(C2=NN([C@H](C3=CC=CC=C3)CC4)C4=N2)=O)CC5)=O)C5=C1
Target:
TNF

References

Patel S, et al. RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death Differ. 2019 May 17.