TargetMol

LAH4 acetate

Product Code:
 
TAR-TP2505L
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TP2505L-1mg1mg£149.00
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TAR-TP2505L-5mg5mg£390.00
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TAR-TP2505L-10mg10mg£546.00
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TAR-TP2505L-25mg25mg£831.00
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TAR-TP2505L-50mg50mg£1,099.00
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Quantity:
TAR-TP2505L-100mg100mg£1,460.00
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This product comes from: United States.
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Further Information

Bioactivity:
LAH4 acetate is the α-helical structure of the designed amphoteric peptide antibiotic, which is capable of complexing DNA, associating with the cell surface membrane and wrapped in the endosome, which is destroyed with the decrease of pH value. It has strong antibacterial, nucleic acid transfection and cell penetration activities. LAH4 acetate has high plasmid DNA transmission capacity. LAH4 acetate has a strong affinity for anions in bacterial membranes.
Molecular Weight:
2839.51
Pathway:
Microbiology/Virology
Purity:
0.9841
SMILES:
OC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC1=CN=CN1)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC2=CN=CN2)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC3=CN=CN3)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Target:
Antibacterial

References

Islami M, et al. Study of orientation and penetration of LAH4 into lipid bilayer membranes: pH and composition dependence. Chem Biol Drug Des. 2014 Aug;84(2):242-52. Moulay G, et al. Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo. J Pept Sci. 2017 Apr;23(4):320-328.