TargetMol

Foxy-5 Ammonium Salt

Product Code:
 
TAR-TP1565L1
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-TP1565L1-1mg1mg£148.00
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TAR-TP1565L1-5mg5mg£327.00
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TAR-TP1565L1-1mL1 mL * 10 mM (in DMSO)£346.00
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TAR-TP1565L1-10mg10mg£454.00
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TAR-TP1565L1-25mg25mg£699.00
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TAR-TP1565L1-50mg50mg£946.00
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Quantity:
TAR-TP1565L1-100mg100mg£1,251.00
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This product comes from: United States.
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Further Information

Bioactivity:
Foxy-5 Ammonium Salt is a WNT5A agonist, a mimetic peptide of WNT5A, a non-classical member of the Wnt family.Foxy-5 Ammonium Salt triggers cytoplasmic free calcium signaling without affecting β-catenin activation and inhibits migration and invasion of epithelial cancer cells.Foxy-5 Foxy-5 Ammonium Salt effectively reduces the metastatic spread of prostate cancer cells with low WNT5A expression in an in situ mouse model.
Molecular Weight:
712.26
Pathway:
Stem Cells|Cytoskeletal Signaling
Purity:
0.977
SMILES:
CSCC[C@H](NC=O)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CS)C(N[C@@H](CCC(O)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O.[NH4+]
Target:
Wnt/beta-catenin

References

Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017;12(9):e0184418. Kelsey R. Prostate cancer: Foxy-5 in prostate cancer model. Nat Rev Urol. 2017;14(11):638. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017;12(9):e0184418. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019;39(4):1719-1728.