TargetMol

AGI-43192

Product Code:
 
TAR-T9729
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T9729-1mg1mg£164.00
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TAR-T9729-5mg5mg£303.00
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TAR-T9729-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T9729-10mg10mg£442.00
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TAR-T9729-25mg25mg£683.00
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TAR-T9729-50mg50mg£930.00
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Quantity:
TAR-T9729-100mg100mg£1,219.00
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Quantity:
TAR-T9729-500mg500mg£2,392.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AGI-43192 is a potent methionine adenosine transferase 2A (MAT2A) inhibitor that penetrates the blood-brain barrier. AGI-43192 inhibits S-adenosine methionine (SAM) production metabolic enzyme and methionine adenosine transferase 2A (MAT2A), which has the potential to study the role of SAM regulation in the central nervous system (CNS) and the treatment of cancer diseases.
CAS:
2377491-54-6
Molecular Weight:
484.86
Purity:
0.996
SMILES:
O=C1C(C=2C=CC(Cl)=CC2)=C3N=C(N=CC3=CN1C=4C=CC5=NN(C=C5C4)C)NCC(F)(F)F

References

Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.