TargetMol

TNIK-IN-3

Product Code:
 
TAR-T9556
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T9556-1mg1mg£177.00
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TAR-T9556-5mg5mg£334.00
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TAR-T9556-1mL1 mL * 10 mM (in DMSO)£362.00
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TAR-T9556-10mg10mg£523.00
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TAR-T9556-25mg25mg£786.00
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TAR-T9556-50mg50mg£1,058.00
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Quantity:
TAR-T9556-100mg100mg£1,412.00
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Quantity:
TAR-T9556-500mg500mg£2,761.00
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Further Information

Bioactivity:
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 uM. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 uM), Flt1 (IC50 = 0.191 uM), and DRAK1 (IC50 = 0.411 uM). This compound holds potential for carrying out research on colorectal cancer (CRC) [1].
CAS:
2754265-25-1
Molecular Weight:
387.41
Pathway:
Cytoskeletal Signaling|Stem Cells
Purity:
0.9956
SMILES:
O=C1C=2C=CC(=CC2OCCN1CC3=CC=C(F)C=C3)C4=CN=C5NC=CC5=C4
Target:
Wnt/beta-catenin

References

Li Y, et, al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5(2 H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Jan 5.