TargetMol

M435-1279

Product Code:
 
TAR-T9500
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T9500-1mg1mg£111.00
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Quantity:
TAR-T9500-5mg5mg£168.00
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Quantity:
TAR-T9500-1mL1 mL * 10 mM (in DMSO)£187.00
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TAR-T9500-10mg10mg£226.00
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TAR-T9500-25mg25mg£369.00
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Quantity:
TAR-T9500-50mg50mg£517.00
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Quantity:
TAR-T9500-100mg100mg£699.00
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Quantity:
TAR-T9500-500mg500mg£1,396.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.
CAS:
1359431-16-5
Molecular Weight:
419.48
Pathway:
Ubiquitination
Purity:
0.9716
SMILES:
O=C(NC1=CC=C(C=C1)S(=O)(=O)N)C=2C(=O)NC=3SC4=C(C3C2O)CCCC4
Target:
E1/E2/E3 Enzyme

References

Yu Z, Jiang X, Qin L, Deng H, Wang J, Ren W, Li H, Zhao L, Liu H, Yan H, Shi W, Wang Q, Luo C, Long B, Zhou H, Sun H, Jiao Z. A novel UBE2T inhibitor suppresses Wnt/?-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene. 2021 Feb;40(5):1027-1042. doi: 10.1038/s41388-020-01572-w. Epub 2020 Dec 15. Erratum in: Oncogene. 2021 Apr;40(14):2622-2623. PMID: 33323973; PMCID: PMC7862066.