TargetMol

Tubulin polymerization-IN-43

Product Code:
 
TAR-T77647
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T77647-1mg1mg£227.00
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TAR-T77647-5mg5mg£416.00
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TAR-T77647-10mg10mg£581.00
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TAR-T77647-25mg25mg£863.00
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TAR-T77647-50mg50mg£1,163.00
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TAR-T77647-100mg100mg£1,540.00
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Quantity:
TAR-T77647-500mg500mg£3,026.00
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Further Information

Bioactivity:
Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell cycle arrest and apoptosis in leukaemia cells. Tubulin polymerisation-IN-43 has multiple effects, promoting leukaemia cell cycle arrest in G2/M phase and apoptosis by targeting Colchicine sites to disrupt the cellular microtubule network.
CAS:
2773345-90-5
Molecular Weight:
351.3
Pathway:
Cytoskeletal Signaling|Apoptosis
Purity:
0.98
SMILES:
FC=1C=CC=2N=C(N=C(C2C1)N(C3=CC=C(OC)C=C3)C)C(F)(F)F
Target:
Apoptosis|Microtubule Associated

References

Wu H, et al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470.