TargetMol

GSK3-IN-3

Product Code:
 
TAR-T73331
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T73331-1mg1mg£98.00
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TAR-T73331-5mg5mg£134.00
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TAR-T73331-10mg10mg£182.00
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TAR-T73331-25mg25mg£303.00
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TAR-T73331-50mg50mg£436.00
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Quantity:
TAR-T73331-100mg100mg£608.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 uM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective against 6-OHDA.
CAS:
331963-27-0
Molecular Weight:
429.55
Pathway:
Autophagy|PI3K/Akt/mTOR signaling|Stem Cells
Purity:
0.98
SMILES:
O=C(NNC(=O)CCCCCCCCCCC)C=1C(=O)N(C=2C=CC=CC2C1O)CC
Target:
Mitophagy|GSK-3

References

Morales-Garc?a JA, et al. Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease. ACS Chem Neurosci. 2013;4(2):350-360. Palomo V, et al. Exploring the binding sites of glycogen synthase kinase Identification and characterization of allosteric modulation cavities. J Med Chem. 2011;54(24):8461-8470. Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021;12(24):4512-4523.