TargetMol

AXL-IN-13

Product Code:
 
TAR-T73300
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T73300-1mg1mg£134.00
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Quantity:
TAR-T73300-5mg5mg£223.00
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Quantity:
TAR-T73300-10mg10mg£295.00
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Quantity:
TAR-T73300-25mg25mg£456.00
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Quantity:
TAR-T73300-50mg50mg£622.00
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Quantity:
TAR-T73300-100mg100mg£872.00
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Quantity:
TAR-T73300-500mg500mg£1,669.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inhibits cancer cell migration and invasion.
CAS:
2376928-82-2
Molecular Weight:
632.72
Pathway:
Angiogenesis|Tyrosine Kinase/Adaptors|Stem Cells
Purity:
0.9938
SMILES:
O=C(NC1CCCCC1)C2=CN(N=C2NC3=CC=C(OC=4C=CN=C5C=C(OCCCN6CCOCC6)C(OC)=CC54)C(F)=C3)C
Target:
TGF-beta/Smad|PDGFR|FLT|TAM Receptor

References

Chan S, et al. Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. J Med Chem. 2022;65(22):15374-15390.