TargetMol

CDK8-IN-12

Product Code:
 
TAR-T72048
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T72048-1mg1mg£134.00
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TAR-T72048-5mg5mg£222.00
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TAR-T72048-1mL1 mL * 10 mM (in DMSO)£229.00
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TAR-T72048-10mg10mg£295.00
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TAR-T72048-25mg25mg£455.00
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TAR-T72048-50mg50mg£621.00
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Quantity:
TAR-T72048-100mg100mg£871.00
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This product comes from: United States.
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Further Information

Bioactivity:
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
CAS:
2613307-67-6
Molecular Weight:
381.86
Pathway:
Stem Cells|Cell Cycle/Checkpoint|PI3K/Akt/mTOR signaling
Purity:
0.9897
SMILES:
O=C1NCCC12CCN(C=3C(Cl)=CN=CC3C=4OC=5C=CC=CC5C4)CC2
Target:
CDK|GSK-3

References

Yu M, et al. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 ; 214:113248.