TargetMol

GTP-14564

Product Code:
 
TAR-T71857
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71857-1mg1mg£102.00
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TAR-T71857-5mg5mg£149.00
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TAR-T71857-10mg10mg£213.00
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TAR-T71857-25mg25mg£362.00
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TAR-T71857-50mg50mg£535.00
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TAR-T71857-100mg100mg£740.00
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Quantity:
TAR-T71857-500mg500mg£1,428.00
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Further Information

Bioactivity:
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 u m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).
CAS:
34823-86-4
Formula:
C15H10N2O
Molecular Weight:
234.25
Pathway:
Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
0.9969
SMILES:
N=1NC2=C(OC=3C=CC=CC32)C1C=4C=CC=CC4
Target:
Tyrosine Kinases|FLT

References

Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003;278(35):32892-32898. Chen W, et al. mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells. Mol Cancer. 2010;9:29