TargetMol

BMS-863233 HCl

Product Code:
 
TAR-T71339
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T71339-1mg1mg£116.00
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TAR-T71339-5mg5mg£168.00
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TAR-T71339-10mg10mg£206.00
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TAR-T71339-25mg25mg£308.00
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TAR-T71339-50mg50mg£470.00
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TAR-T71339-100mg100mg£651.00
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Quantity:
TAR-T71339-500mg500mg£1,291.00
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Further Information

Bioactivity:
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.BMS-863233 HCl showed an EC50 value of 118 against pMCM.
CAS:
1169562-71-3
Molecular Weight:
326.18
Pathway:
Cell Cycle/Checkpoint|JAK/STAT signaling|Metabolism|Chromatin/Epigenetic|Stem Cells
Purity:
0.9942
SMILES:
Cl.Clc1ccc2oc3c([nH]c(nc3=O)[C@@H]3CCCN3)c2c1
Target:
Casein Kinase|Pim|CDK

References

Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor [published correction appears in Bioorg Med Chem Lett. 2012 Aug 1;22(15):5157]. Bioorg Med Chem Lett. 2012;22(11):3727-3731. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014;9(11):e113300.