TargetMol

Pinokalant

Product Code:
 
TAR-T70540
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T70540-1mg1mg£227.00
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TAR-T70540-5mg5mg£416.00
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TAR-T70540-10mg10mg£581.00
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TAR-T70540-25mg25mg£863.00
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TAR-T70540-50mg50mg£1,163.00
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Further Information

Bioactivity:
Pinokalant is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region, and reduces the size of the lesion on magnetic resonance images in the acute phase after middle cerebral artery occlusion in rats.Pinokalant is a potential SARS-CoV-2 protease inhibitor for the study of stroke.
CAS:
149759-26-2
Molecular Weight:
712.83
Pathway:
Microbiology/Virology|Membrane transporter/Ion channel
Purity:
0.9909
SMILES:
O=C(N(CCC1=CC=C(OC)C(OC)=C1OC)CCC2=CC=C(OC)C(OC)=C2OC)C(C3=NCCC=4C=C(OC)C(OC)=CC34)C=5C=CC=CC5
Target:
SARS-CoV|TRP/TRPV Channel

References

Christensen T, et al. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005;96(4):316-324. Serdar Durdagi, et al. Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study. 2020. Simard JM, et al. Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta. 2007;1772(8):947-957.