TargetMol

ZD-2138

Product Code:
 
TAR-T68173
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68173-1mg1mg£177.00
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TAR-T68173-5mg5mg£328.00
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TAR-T68173-10mg10mg£448.00
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TAR-T68173-25mg25mg£691.00
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TAR-T68173-50mg50mg£938.00
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Quantity:
TAR-T68173-100mg100mg£1,243.00
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Quantity:
TAR-T68173-500mg500mg£2,416.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.ZD-2138 can be used for the treatment of asthma disease.
CAS:
140841-32-3
Molecular Weight:
397.44
Pathway:
Metabolism
Purity:
1
SMILES:
O=C1C=CC=2C=C(C=CC2N1C)COC3=CC(F)=CC(=C3)C4(OC)CCOCC4
Target:
Lipoxygenase

References

Werz O, et al. Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. Mol Pharmacol. 1998;54(2):445-451. McAlexander MA, et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. J Pharmacol Exp Ther. 1998;285(2):602-607.