TargetMol

Pafenolol

Product Code:
 
TAR-T68124
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68124-1mg1mg£140.00
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TAR-T68124-5mg5mg£231.00
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TAR-T68124-10mg10mg£311.00
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TAR-T68124-25mg25mg£541.00
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TAR-T68124-50mg50mg£713.00
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TAR-T68124-100mg100mg£946.00
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Quantity:
TAR-T68124-500mg500mg£1,862.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 uM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
CAS:
75949-61-0
Molecular Weight:
337.46
Pathway:
Membrane transporter/Ion channel|GPCR/G Protein|Neuroscience
Purity:
0.9843
SMILES:
O=C(NCCC1=CC=C(OCC(O)CNC(C)C)C=C1)NC(C)C
Target:
P-gp|Adrenergic Receptor

References

Regardh CG, et al. Pharmacokinetics of pafenolol after i.v. and oral administration of three separate doses of different strength to man. Biopharm Drug Dispos. 1990;11(7):607-617. Lennern?s H, et al. Regional gastrointestinal absorption of the beta-blocker pafenolol in the rat and intestinal transit rate determined by movement of 14C-polyethylene glycol (PEG) 4000. Pharm Res. 1993;10(1):130-135. L?fdahl CG, et al. Pafenolol, a highly selective beta 1-adrenoceptor-antagonist, in asthmatic patients: interaction with terbutaline. Clin Pharmacol Ther. 1983;33(1):1-9. Dahl?f B, et al. Pafenolol in hypertension: a double-blind randomized trial of a new beta 1-selective adrenoceptor blocker. J Cardiovasc Pharmacol. 1986;8(1):55-59. Lennern?s H, et al. Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat. Pharm Res. 1993;10(5):727-731.