TargetMol

Spiroglumide

Product Code:
 
TAR-T68016
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68016-1mg1mg£197.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T68016-5mg5mg£384.00
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Quantity:
TAR-T68016-10mg10mg£544.00
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Quantity:
TAR-T68016-25mg25mg£828.00
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Quantity:
TAR-T68016-50mg50mg£1,099.00
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Quantity:
TAR-T68016-100mg100mg£1,460.00
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Quantity:
TAR-T68016-500mg500mg£2,850.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Spiroglumide, a CCKB-gastrin antagonist that inhibits dose-dependent pentagastrin-induced acid hypersecretion with an ID50 of 20.1 (8.67-46.4) mg / kg, could be used to explore the physiological role of gastrin in the regulation of human gastric acid secretion.
CAS:
137795-35-8
Molecular Weight:
301.81
Pathway:
GPCR/G Protein
Purity:
0.9834
SMILES:
Cl.O=C(OC1=CC=CC(=C1)C(O)CNCC)C(C)(C)C
Target:
cholecystokinin

References

Makovec F, et al. Structure-antigastrin activity relationships of new spiroglumide amido acid derivatives. J Med Chem. 1996;39(1):135-142. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996;10(3):411-419.