TargetMol

Fuzapladib

Product Code:
 
TAR-T67749
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67749-1mg1mg£149.00
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TAR-T67749-5mg5mg£269.00
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TAR-T67749-1mL1 mL * 10 mM (in DMSO)£356.00
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TAR-T67749-10mg10mg£369.00
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TAR-T67749-25mg25mg£703.00
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TAR-T67749-50mg50mg£1,058.00
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Quantity:
TAR-T67749-100mg100mg£1,669.00
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Quantity:
TAR-T67749-500mg500mg£3,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fuzapladib (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis.
CAS:
141283-87-6
Molecular Weight:
379.4
Pathway:
Metabolism
Purity:
0.9965
SMILES:
O=C(NC1=CC(=CN=C1NS(=O)(=O)CC)C(F)(F)F)C2CCCCC2
Target:
Phospholipase

References

Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. Fukunaga T, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9.