TargetMol

PRI-724

Product Code:
 
TAR-T64414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T64414-1mg1mg£164.00
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TAR-T64414-5mg5mg£270.00
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TAR-T64414-10mg10mg£389.00
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TAR-T64414-1mL1 mL * 10 mM (in DMSO)£405.00
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TAR-T64414-25mg25mg£603.00
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TAR-T64414-50mg50mg£830.00
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Quantity:
TAR-T64414-100mg100mg£1,099.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PRI-724 is a selective small-molecule inhibitor of β-catenin/CBP interaction.
CAS:
1422253-38-0
Formula:
C33H35N6O7P
Molecular Weight:
658.64
Pathway:
Stem Cells|Cytoskeletal Signaling
Purity:
0.9911
SMILES:
C([C@@H]1N2[C@@](N(C(NCC3=CC=CC=C3)=O)N(C)CC2=O)([C@H](C)N(CC=4C5=C(C=CC4)C=CC=N5)C1=O)[H])C6=CC=C(OP(=O)(O)O)C=C6
Target:
Wnt/beta-catenin

References

PRI-724 reduces liver fibrosis, and hepatic hydroxyproline levels, in HCV mice while attenuating ?SMA induction. PRI-724 increased the levels of matrix metalloproteinase (MMP)-8 mRNA in the liver, along with elevated levels of intrahepatic neutrophils and macrophages/monocytes. In conclusion, PRI-724 ameliorates HCV-induced liver fibrosis in mice. PRI-724 is a drug candidate which possesses antifibrotic effect[1].