TargetMol

NRX-103094

Product Code:
 
TAR-T63427
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T63427-1mg1mg£131.00
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Quantity:
TAR-T63427-5mg5mg£204.00
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Quantity:
TAR-T63427-10mg10mg£303.00
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Quantity:
TAR-T63427-25mg25mg£537.00
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Quantity:
TAR-T63427-50mg50mg£804.00
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Quantity:
TAR-T63427-100mg100mg£1,171.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
CAS:
2763260-36-0
Molecular Weight:
503.28
Pathway:
Stem Cells|Cytoskeletal Signaling
Purity:
0.995
SMILES:
O=C(O)C=1C=CC=C(C1)NC(=O)C=2C(=O)NC(=CC2SC=3C(Cl)=CC=CC3Cl)C(F)(F)F
Target:
Wnt/beta-catenin

References

Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.