TargetMol

CHD1Li 6.11

Product Code:
 
TAR-T63049
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63049-1mg1mg£145.00
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TAR-T63049-5mg5mg£254.00
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TAR-T63049-1mL1 mL * 10 mM (in DMSO)£262.00
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TAR-T63049-10mg10mg£369.00
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TAR-T63049-25mg25mg£576.00
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TAR-T63049-50mg50mg£790.00
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Quantity:
TAR-T63049-100mg100mg£1,050.00
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Quantity:
TAR-T63049-500mg500mg£2,038.00
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This product comes from: United States.
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Further Information

Bioactivity:
CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 uM). CHD1Li 6.11 is an orally active antitumour agent that significantly reduces the tumour volume of CRC xenografts generated from isolated quasi-mesenchymal cells (M phenotype) with enhanced tumourigenic properties. These cells have enhanced tumourigenic properties.
CAS:
2716890-91-2
Molecular Weight:
472.4
Purity:
0.9803
SMILES:
O=C(NC1=CC=C(C=C1)NC2=NC(=NC(=C2)C)N3CCCC3)CC=4SC=C(Br)C4

References

Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022;65(5):3943-3961.