TargetMol

PF-03463275

Product Code:
 
TAR-T61564
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61564-1mg1mg£111.00
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TAR-T61564-5mg5mg£168.00
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TAR-T61564-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T61564-10mg10mg£229.00
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TAR-T61564-25mg25mg£338.00
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TAR-T61564-50mg50mg£519.00
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Quantity:
TAR-T61564-100mg100mg£627.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
CAS:
1173239-39-8
Molecular Weight:
376.86
Pathway:
Neuroscience
Purity:
0.98
SMILES:
C(N(C(=O)C=1N=CN(C)C1)CC2=CC(Cl)=C(F)C=C2)[C@@H]3[C@@]4([C@]3(CN(C)C4)[H])[H]
Target:
GlyT

References

Lowe JA 3rd, et al. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter [published correction appears in Bioorg Med Chem Lett. 2009 Aug 15;19(16):4885. Liu CN, Pettersen B, Seitis G, Osgood S, Somps C. GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats. Cutan Ocul Toxicol. 2014;33(3):206-211.