TargetMol

APX2039

Product Code:
 
TAR-T61355
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61355-1mg1mg£229.00
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TAR-T61355-1mL1 mL * 10 mM (in DMSO)£442.00
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TAR-T61355-5mg5mg£535.00
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TAR-T61355-10mg10mg£736.00
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TAR-T61355-25mg25mg£1,083.00
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TAR-T61355-50mg50mg£1,428.00
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Quantity:
TAR-T61355-100mg100mg£1,902.00
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This product comes from: United States.
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Further Information

Bioactivity:
APX2039 is an orally active fungal Gwt1 enzyme inhibitor and a prodrug of the novel Gwt2096 inhibitor APX1.APX2039 exhibits potent anti-Kryptococcal activity against C. neoformans and C. gattii.APX2039 exhibits potent antifungal activity and blocks the localization of GPI (glycosylphosphatidylinositol) anchored cell wall mannoproteins. APX2039 has potent antifungal activity and blocks the localization of GPI (glycosylphosphatidylinositol)-anchored cell wall mannoproteins.APX2039 can be used to study cryptococcal meningitis (CM).
CAS:
2342606-49-7
Molecular Weight:
362.36
Pathway:
Microbiology/Virology
Purity:
0.9785
SMILES:
FC=1N=C(OC2=CC=C(C=C2)CC3=NOC(=C3)C=4C=CC=NC4N)C=CC1
Target:
Antifungal

References

Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31. Yu CH, et al. Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. mBio. 2021 Dec 21;12(6):e0231321.