TargetMol

tetranor-PGDM

Product Code:
 
TAR-T38306
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T38306-1mg1mgEnquire
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Further Information

Bioactivity:
Prostaglandin D2 is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. PGD2 is also produced in the brain by lipocalin-PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and mouse urine. The levels of tetranor-PGDM and 2,3-dinor-11β-PGF2α , a related PGD2 metabolite, in human urine were found to be 1.5 ? 0.3 and 0.6 ? ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ? 1.3 ng/mg creatinine.
CAS:
70803-91-7
Formula:
C16H24O7
Molecular Weight:
328.361
Purity:
0.98
SMILES:
O[C@H]1CC(=O)[C@H](CCC(=O)CCCCC(O)=O)[C@H]1CCC(O)=O