TargetMol

Cytostatin

Product Code:
 
TAR-T37055
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T37055-1mg1mgEnquire
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Further Information

Bioactivity:
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 ug/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 ug/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
CAS:
682329-63-1
Molecular Weight:
428.462
Purity:
0.98
SMILES:
[H][C@]1(OC(=O)C=C[C@@H]1C)[C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)\C=C/C=C\C=C\C |c:5|