TargetMol

DN401

Product Code:
 
TAR-T27193
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T27193-1mg1mg£227.00
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TAR-T27193-1mL1 mL * 10 mM (in DMSO)£414.00
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TAR-T27193-5mg5mg£416.00
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TAR-T27193-10mg10mg£581.00
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TAR-T27193-25mg25mg£863.00
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TAR-T27193-50mg50mg£1,163.00
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TAR-T27193-100mg100mg£1,540.00
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TAR-T27193-500mg500mg£3,026.00
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This product comes from: United States.
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Further Information

Bioactivity:
DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.
CAS:
2135749-60-7
Formula:
C18H19N3O2
Molecular Weight:
309.36
Pathway:
Cytoskeletal Signaling|Metabolism
Purity:
1
SMILES:
N=1N=C(C)CC=2C=C(OC)C(OC)=CC2C1C=3C=CC(N)=CC3
Target:
HSP

References

Kim D, et al. Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg Chem. 2020;101:103901. Park HK, et al. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J Med Chem. 2017;60(17):7569-7578.