TargetMol

Lactimidomycin

Product Code:
 
TAR-T15703
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T15703-1mg1mgEnquire
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Further Information

Bioactivity:
Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It inhibits protein synthesis (IC50: 37.82 nM).
CAS:
134869-15-1
Formula:
C26H35NO6
Molecular Weight:
457.56
Purity:
0.98
SMILES:
C([C@H](CC([C@H](/C=C(\C)/[C@H]1[C@@H](C)\C=C/C=C/CC\C=C\C(=O)O1)C)=O)O)C2CC(=O)NC(=O)C2

References

Schneider-Poetsch T, et al. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol. 2010 Mar;6(3):209-217. Carocci M, et al. Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses. Antiviral Res. 2016 Apr;128:57-62.