TargetMol

Didesmethyl cariprazine

Product Code:
 
TAR-T15117
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T15117-1mg1mg£214.00
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TAR-T15117-5mg5mg£436.00
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TAR-T15117-1mL1 mL * 10 mM (in DMSO)£464.00
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TAR-T15117-10mg10mg£610.00
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TAR-T15117-25mg25mg£922.00
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TAR-T15117-50mg50mg£1,219.00
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TAR-T15117-100mg100mg£1,613.00
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TAR-T15117-500mg500mg£3,163.00
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Further Information

Bioactivity:
Didesmethyl cariprazine, a metabolite of Cariprazine, is the major cyclic active part. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a potent D3 preference D3/D2 receptor partial agonist of dopamine for the treatment of schizophrenia, bipolar mania, and depression, with a high affinity for d3 and d2 receptors and a moderate affinity for 5-HT 1A receptors.
CAS:
839712-25-3
Formula:
C19H28Cl2N4O
Molecular Weight:
399.36
Pathway:
Neuroscience|GPCR/G Protein
Purity:
0.997
SMILES:
ClC1=C(N2CCN(CC[C@H]3CC[C@H](NC(N)=O)CC3)CC2)C=CC=C1Cl
Target:
Dopamine Receptor|5-HT Receptor

References

Citrome L. Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013;9(2):193-206. Citrome L, et al. Cariprazine for acute and maintenance treatment of adults with schizophrenia: an evidence-based review and place in therapy. Neuropsychiatr Dis Treat. 2018;14:2563-2577.