TargetMol

5Z-7-Oxozeaenol

Product Code:
 
TAR-T14055
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T14055-1mg1mg£334.00
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Further Information

Bioactivity:
5Z-7-Oxozeaenol is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
CAS:
253863-19-3
Formula:
C19H22O7
Molecular Weight:
362.37
Pathway:
Microbiology/Virology|MAPK|Tyrosine Kinase/Adaptors|Angiogenesis
Purity:
0.98
SMILES:
C[C@@H](C/C=C\C([C@H]([C@H](C/C=C/c1cc(OC)cc(O)c11)O)O)=O)OC1=O
Target:
Antibiotic|PDGFR|FLT|MEK|MAPK|Src|VEGFR

References

Takehana K, et al. A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner. Biochem Biophys Res Commun. 1999 Apr 2;257(1):19-23. Dakas PY, et al. Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors. Angew Chem Int Ed Engl. 2007;46(36):6899-902.