TargetMol

EGFR-IN-11

Product Code:
 
TAR-T11158
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T11158-1mg1mg£177.00
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TAR-T11158-5mg5mg£334.00
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TAR-T11158-1mL1 mL * 10 mM (in DMSO)£405.00
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TAR-T11158-10mg10mg£523.00
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TAR-T11158-25mg25mg£786.00
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TAR-T11158-50mg50mg£1,058.00
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Quantity:
TAR-T11158-100mg100mg£1,412.00
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Quantity:
TAR-T11158-500mg500mg£2,761.00
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This product comes from: United States.
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Further Information

Bioactivity:
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1.
CAS:
2463200-44-2
Formula:
C29H35N9O2S
Molecular Weight:
573.71
Pathway:
Tyrosine Kinase/Adaptors|JAK/STAT signaling|Angiogenesis
Purity:
0.9937
SMILES:
N(C=1N(C=2C(N1)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)[C@H]5CN(S(=O)(=O)C6CC6)CC5)C7=CC=CC=C7
Target:
EGFR

References

Lei H, et al. Discovery of novel 9-heterocyclyl substituted 9H-purines as L858R/T790M/C797S mutant EGFR tyrosine kinase inhibitors. Eur J Med Chem. 2019 Nov 16:111888.