TargetMol

Cot inhibitor-1 hydrochloride

Product Code:
 
TAR-T10865L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T10865L-1mg1mg£173.00
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TAR-T10865L-5mg5mg£274.00
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TAR-T10865L-1mL1 mL * 10 mM (in DMSO)£309.00
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TAR-T10865L-10mg10mg£390.00
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TAR-T10865L-25mg25mg£605.00
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TAR-T10865L-50mg50mg£831.00
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Quantity:
TAR-T10865L-100mg100mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 = 5.7 nM).
CAS:
T10865L
Formula:
C27H28Cl3FN8
Molecular Weight:
589.92
Pathway:
MAPK|Apoptosis
Purity:
0.9826
SMILES:
N#CC1=CN=C2C(Cl)=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC2=C1NC5=CC=C(C(Cl)=C5)F.Cl
Target:
MAPK|TNF

References

Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.