TPM1 Antibody / Tropomyosin-1 / Alpha Tropomyosin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody.

This Alpha Tropomyosin antibody is available for research use only.

Cytoplasm, Cytoskeleton

Protein A/G affinity

P04268