CD3 epsilon Antibody

Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A recombinant partial protein (within amino acids 1-200) from the human protein was used as the immunogen for the CD3e antibody.

This CD3e antibody is available for research use only.

Cell surface, Cytoplasm

Protein A/G affinity

P07766