Diaclone

Mouse Anti-Human IL-12 p35 BioActive Antibody, Clone B-T21, Azide free

Product Code:
 
855.120.000
Product Group:
 
Primary Antibodies
Supplier:
 
Diaclone
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
B-T21
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Functional Study
 

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855.120.000200ug/200ul£232.00
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  • Further Information
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Further Information

Activity:
Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
Antigen:
IL-12p35+p70
Antigen Synonyms:
IL-12p35/p70
Biological Acivity:
Inhibits IL-12 induced IFNg synthesis on PHA activated lymphocytes
Conjugate:
Azide free
Format:
Azide free
Hybridoma:
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation:
Recombinant human IL-12
Reactivity:
Human
Research Area:
Cytokines / Growth FactorsInnate Immunity
Specificity:
Recognises both natural and recombinant human IL-12 p35 + p70

References

  1. Kolanowski S. T. H. M. et al. Innate Immunity2013: 1753425913498626.. TLR4-mediated pro-inflammatory dendritic cell differentiation in humans requires the combined action of MyD88 and TRIF.. https://www.ncbi.nlm.nih.gov/pubmed/23941760
  2. Nagai T. et al. J Immunol.2003; 171(10): 5233-43.. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. https://www.ncbi.nlm.nih.gov/pubmed/14607924
  3. Oppmann B. et al. Immunity2000; 13(5): 715-25.. Novel p19 protein engages IL-12p40 to form a cytokine IL-23 with biological activities similar as well as distinct from IL-12.. https://www.ncbi.nlm.nih.gov/pubmed/11114383