Gamma Catenin Antibody / Plakoglobin

Immunofluorescence: 1-2ug/ml,Western blot: 0.5-1ug/ml,Flow cytometry: 1-2ug/million cells

Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

It recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (α, β, γ and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. α T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. α T-catenin binds to α E-catenin as well as to β-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for α-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

This Plakoglobin antibody is available for research use only.

Cell surface, cytoplasmic, cell junctions

Protein G affinity chromatography

P14923