BMPR2 Antibody

IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Titration of the BMPR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 27-56 from the human protein was used as the immunogen for this BMPR2 antibody.

This BMPR2 antibody is available for research use only.

Purified

Q13873